Fig. 6: MALAT1 promotes HUVEC tube formation and cardiomyocyte survival. | Cell Death & Disease

Fig. 6: MALAT1 promotes HUVEC tube formation and cardiomyocyte survival.

From: Extracellular vesicles from human embryonic stem cell-derived cardiovascular progenitor cells promote cardiac infarct healing through reducing cardiomyocyte death and promoting angiogenesis

Fig. 6

a The abundance of exogenous MALAT1 was significantly increased in cardiac tissue of the MI + EV group (n = 7) compared with the sham group (n = 4) and the MI group (n = 5). b The MALAT1 abundance was significantly upregulated in the NRCMs treated with hCVPC-EVs. n = 3. c Cell viability in the MALAT1-overexpressing NRCMs with and without OGD injury. n = 9. d MALAT1 was knocked down in the HUVECs with the MALAT1 GapmeR. n = 5. e MALAT1 GapmeR inhibited hCVPC-EV-promoted HUVECs tube formation n = 3 each. Scale bar, 100 μm. *p < 0.05, **p < 0.01, ***p < 0.001.

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