Fig. 5: Expressional changes of signaling molecules of apoptosis, inflammation, fibrosis, and tissue repair in the heart tissues. | Cell Death & Disease

Fig. 5: Expressional changes of signaling molecules of apoptosis, inflammation, fibrosis, and tissue repair in the heart tissues.

From: The adipokine Retnla deficiency increases responsiveness to cardiac repair through adiponectin-rich bone marrow cells

Fig. 5

Heart tissues were collected at day 2 (A–C) and 14 (D–F) after MI to analyzed signaling molecules. BCL2-associated agonist of cell death (BAD), BCL2-associated X, apoptosis regulator (BAX), and Fas ligand (FasL) are cell death-related molecules. Collagen type IV, α5 (Col4α5), collagen type V, α3 (Col5α3), and transforming growth factor-β1 (TGF-β1) are fibrosis-related molecules. Tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), IL-10, and toll-like receptor 2 (TLR2) are inflammation-related molecules. G–I Circulating levels of interleukin-6 (IL-6), IL-1β, and IL-18 in WT mice (n = 5) and KO mice (n = 5) with or without MI were measured. Data are represented as mean ± SEM. #P < 0.05, ##P < 0.01, ###P < 0.001 (by Student’s t test). J Schematic representation showing the proliferative bone marrow milieu with high adiponectin is associated with improved cardiac repair in infarcted myocardium. The images of bone (https://www.onlinewebfonts.com/icon/559079) and heart (https://www.onlinewebfonts.com/icon/493852) is obtained from clipart library, and used under the Creative Commons Attribution-Share Alike 4.0 International license (http://creativecommons.org/licenses/by-sa/4.0/).

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