Fig. 2: The effect of RNF157-AS1 on EOC cell proliferation, apoptosis, invasion, and migration. | Cell Death & Disease

Fig. 2: The effect of RNF157-AS1 on EOC cell proliferation, apoptosis, invasion, and migration.

From: Differential effects of the LncRNA RNF157-AS1 on epithelial ovarian cancer cells through suppression of DIRAS3- and ULK1-mediated autophagy

Fig. 2

A The CCK8 assay showed that RNF157-AS1 inhibition led to a significant decrease in the viability of SKOV3 and A2780 cells while RNF157-AS1 overexpression increased the proliferation rate of EOC cells. B The clone formation assay indicated that RNF157-AS1 knockdown significantly decreased the viability of SKOV3 and A2780 cells while RNF157-AS1 overexpression enhanced the proliferation of SKOV3 and A2780 cells. C The flow cytometry assay suggested RNF157-AS1 knockdown or overexpression had little effect on EOC cell apoptosis. D The transwell assay showed that RNF157-AS1 overexpression enhanced the invasion and migration of SKOV3 and A2780 cells but RNF157-AS1 depletion attenuated the invasion and migration of SKOV3 and A2780 cells. Data were obtained from at least three independent experiments. *P < 0.05; **P < 0.01 (t-test).

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