Fig. 7: RNF157-AS1 reduced the viability and promoted the apoptosis of EOC cells under a DDP environment. | Cell Death & Disease

Fig. 7: RNF157-AS1 reduced the viability and promoted the apoptosis of EOC cells under a DDP environment.

From: Differential effects of the LncRNA RNF157-AS1 on epithelial ovarian cancer cells through suppression of DIRAS3- and ULK1-mediated autophagy

Fig. 7

A Treatment with DDP (2 μM) for 48 h, RNF157-AS1 overexpression significantly reduced SKOV3 and A2780 cell viability but RNF157-AS1 depletion enhanced EOC cell viability. B Treatment with DDP (2 μM) for 48 h, RNF157-AS1 interference markedly reduced the apoptosis rate of SKOV3 and A2780 cells and RNF157-AS1 overexpression increased the apoptosis rate of EOC cells. C and D Under the DDP environment, RNF157-AS1 depletion increased MDC staining and decreased IP staining. on the contrary, RNF157-AS1 overexpression elevated MDC staining and diminished IP staining. The bar represents 100 μm. Data were obtained from at least three independent experiments. *P < 0.05; **P < 0.01 (t-test).

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