Fig. 1: The renal mitochondrial protein acetylome identified PDHA1 hyperacetylation after CLP. | Cell Death & Disease

Fig. 1: The renal mitochondrial protein acetylome identified PDHA1 hyperacetylation after CLP.

From: PDHA1 hyperacetylation-mediated lactate overproduction promotes sepsis-induced acute kidney injury via Fis1 lactylation

Fig. 1

A Flow chart showing the mitochondrial protein acetylome in the mouse kidney 8 h after CLP (n = 3). B Volcano plot showing the differentially modified proteins. C The number of differentially modified proteins. D Subcellular localization of the differentially modified proteins. E Biological processes of the differentially modified proteins. F Differentially modified proteins involved in cellular respiration, the tricarboxylic acid cycle, and oxidative phosphorylation. G Differential PDHA1 acetylated lysine sites. H, I Mass spectrometry spectrum of the acetylated PDHA1 K267 and K385 sites. J Protein multiple sequence alignment analysis of the PDHA1 267 and 385 sites.

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