Fig. 6: The proposed model of BAP1 promotes MYCN stabilization and mediates the drug sensitivity of NB cells. | Cell Death & Disease

Fig. 6: The proposed model of BAP1 promotes MYCN stabilization and mediates the drug sensitivity of NB cells.

From: Deficiency of BAP1 inhibits neuroblastoma tumorigenesis through destabilization of MYCN

Fig. 6

A BAP1 promotes MYCN deubiquitination and stabilization as a deubiquitinase of MYCN. The NB cells with wide-type BAP1 are sensitive to JQ1 and Alisertib. B Downregulation of BAP1 by shRNA or siRNA to reduce MYCN level will retard the NB cell proliferation and growth. C Deficiency of BAP1 in NB cells confers resistance to JQ1 and Alisertib in a MYCN-dependent manner.

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