Fig. 8: The neuroprotective effects of CEC-EVs in LPS-induced behavioral deficits in mice. | Cell Death & Disease

Fig. 8: The neuroprotective effects of CEC-EVs in LPS-induced behavioral deficits in mice.

From: Cerebral endothelial cell-derived extracellular vesicles regulate microglial polarization and promote autophagy via delivery of miR-672-5p

Fig. 8

A Representative traces indicating the paths of the mice in the space exploration and orientation navigation test. B CEC-EVs treatment reduced the time spent to find the submerged platform. CEC-EVs treatment enhanced the number of crossing (C) and reduced the time spent on exploring the quadrant that initially contained the platform (D). E Representative heat maps showing EPM results. CEC-EVs treatment increased number of open arm entries (F) and time spent in the open arm of the EPM test (G). H CEC-EVs treatment increased sucrose preference in the SPT. I CEC-EVs treatment decreased immobility time in the FST. All data are present as means ± SD (n = 12). One-way ANOVA. **p < 0.01 compared to Control group. #p < 0.05, ##p < 0.01 compared to LPS group. &p < 0.05, &&p < 0.01 compared to LPS + miR-NCKD-EVs group.

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