Fig. 8: NRF2 depletion exacerbates IMQ-induced psoriasis-like symptoms and negates the therapeutic effect of SFN. | Cell Death & Disease

Fig. 8: NRF2 depletion exacerbates IMQ-induced psoriasis-like symptoms and negates the therapeutic effect of SFN.

From: Sulforaphane alleviates psoriasis by enhancing antioxidant defense through KEAP1-NRF2 Pathway activation and attenuating inflammatory signaling

Fig. 8

a Wild-type (WT) and NRF2−/− mice were topically treated with IMQ for seven consecutive days and sacrificed on day 8. Images were taken on day 4 and day 8. n = 5. b The PASI scores of the skin tissue. c p-STAT3, STAT3, p-P65, P65, p-IκBα, IκB, K16 and NQO1 expression was detected using Western blotting. d The relative expression levels of protein were analyzed by normalization to GAPDH. e H&E staining (magnification × 100) and immunohistochemical staining of Ki67, K17 and K16 (magnification × 200) in skin sections of mice were performed. f The average epidermal thickness (μM), derived from 18–20 random measurements. g qRT–PCR was performed to evaluate the mRNA expression of Il17a and Il23a in mouse skin. n = 3. *p < 0.05, **p < 0.01 and ***p < 0.001.

Back to article page