Fig. 1: UVB irradiation causes epidermal differentiation and metabolic changes in human epidermal equivalents. | Cell Death & Disease

Fig. 1: UVB irradiation causes epidermal differentiation and metabolic changes in human epidermal equivalents.

From: FBP1 orchestrates keratinocyte proliferation/differentiation and suppresses psoriasis through metabolic control of histone acetylation

Fig. 1

a Sample correlation analysis of the transcriptome of human epidermal equivalents from the control group, UVB_24 h group and UVB_72 h group. b Principal component analysis of the transcriptome of human epidermal equivalents from the control group, UVB_24 h group and UVB_72 h group. c Clustering heatmap of the 1227 differentially expressed genes based on FPKM. d, e Over-representation analysis of GO (d) and KEGG pathways (e) based on the 1227 differentially expressed genes. The size indicates the gene numbers and the color corresponds to the P value. f Gene set enrichment analysis (GSEA) of differentially expressed genes in the UVB_24 h group relative to the control group, UVB_72 h group relative to the control group and UVB_72 h group relative to the UVB_24 h group. g Expression heatmap of the top 10 changed genes.

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