Fig. 10: Summary of the key findings of this study.
From: O-GlcNAcylation controls pro-fibrotic transcriptional regulatory signaling in myofibroblasts
Schematic depicting how O-GlcNAcylation connects metabolic and transcriptomic reprogramming driving myofibroblastic activation during organ repair or fibrosis by targeting key MF TRs such as BNC2, TEAD4, and YAP1. Notably, O-GlcNAcylation plays a critical role in stabilizing the BNC2, TEAD4, and YAP1 proteins, enabling the assembly of pro-fibrotic transcriptional regulatory complexes required for establishment of the active epigenome and transcriptome of MFs.
