Fig. 4: Interaction between BCKDK and G6PD influencing protein stability. | Cell Death & Disease

Fig. 4: Interaction between BCKDK and G6PD influencing protein stability.

From: MAZ-mediated up-regulation of BCKDK reprograms glucose metabolism and promotes growth by regulating glucose-6-phosphate dehydrogenase stability in triple-negative breast cancer

Fig. 4

a Interaction model of BCKDK (blue) and G6PD (green). Red indicates interaction sites. b Co-immunoprecipitation of BCKDK with G6PD. c Representative images of green fluorescence from BCKDK co-localised with red fluorescence from G6PD. d BCKDK did not substantially affect G6PD RNA expression but positively influenced protein expression. e G6PD degradation analysis over different time points between BCKDK (lower) and Vector (upper) groups in BT-549 and MDA-MB-231 cells. f MG132, a proteasome inhibitor, did not affect the degradation of G6PD in the shBCKDK and shCtrl groups.

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