Fig. 7: PA treatment suppresses tumor growth in vivo. | Cell Death & Disease

Fig. 7: PA treatment suppresses tumor growth in vivo.

From: Prosapogenin A induces GSDME-dependent pyroptosis of anaplastic thyroid cancer through vacuolar ATPase activation-mediated lysosomal over-acidification

Fig. 7

A Growth curves of 8505C xenograft tumors in BALB/c nude mice treated with PA (10 mg/kg, 20 mg/kg), CQ (60 mg/kg), and PA (10 mg/kg) in combination with CQ (60 mg/kg) (n = 5/group), xenograft tumor volumes were measured every other day. B The tumors were dissected and weighted at day 15 after treatment. C Representative photographs of isolated tumors at day 15 after treatment. D Ki-67, ATP6V1A, ATP6V1B2, ATP6V0C, cleaved-caspase 8/3 expression levels in xenograft tumors as measured by IHC staining assay, (scale bar: 100 μm). Data are shown as mean ± SD for n = 5 (biological replicates). *p < 0.05, **p < 0.01, ***p < 0.001.

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