Fig. 5: SPARC knockdown partially reverses GC progression induced by LCN2-knockdown in vivo. | Cell Death & Disease

Fig. 5: SPARC knockdown partially reverses GC progression induced by LCN2-knockdown in vivo.

From: Tumor-secreted LCN2 impairs gastric cancer progression via autocrine inhibition of the 24p3R/JNK/c-Jun/SPARC axis

Fig. 5

A–C Image of xenograft tumor samples (A), tumor volumes (B), and tumor weights (C) derived from mice injected with the indicated cells. D Representative images of HE staining and IHC staining for LCN2, Ki-67, and SPARC of each group (n = 6). Scale bar:100 μm; E Representative HE staining images of lung samples from the indicated groups. Scale bars:1.25 mm (upper panel) and 200 μm (lower panel). F Quantitative results of the metastatic nodes of the lungs in (E). G Images of the popliteal lymph nodes of mice injected with the indicated cells. H Volume of the popliteal lymph nodes in (G). I Representative HE staining images of the popliteal lymph nodes in (G). Scale bars:1.25 mm (upper panel) and 100 μm (lower panel). J Percentage of metastatic and non-metastatic popliteal lymph nodes in the indicated groups. Data are presented as mean ± SD of three independent experiments. *p < 0.05, **p < 0.01, ***p < 0.001.

Back to article page