Fig. 2: Inhibition of CYP monooxygenases alleviates BC tumor progression in mice. | Cell Death & Disease

Fig. 2: Inhibition of CYP monooxygenases alleviates BC tumor progression in mice.

From: Epoxy metabolites of linoleic acid promote the development of breast cancer via orchestrating PLEC/NFκB1/CXCL9-mediated tumor growth and metastasis

Fig. 2

A Scheme of the animal study, here we adopted a spontaneous mice model of BC in MMTV-PyMT mice; B Time course of mouse tumor growth, tumor size of each mouse was measured once a week (n = 13); C Representative images of tumors collected from one mouse of the MMTV-PyMT mice treated without/with clotrimazole (Clo) or proadifen hydrochloride (SKF); Statistical analysis of the number (D), weight (E) and volume (F) of tumors in MMTV-PyMT mice treated without/with Clo (n = 12) or SKF (n = 13); G Increased mRNA expression of Cyp2j8 in tumor tissues for MMTV-PyMT mice was significantly reduced by the treatment of Clo and SKF (n = 9); H, I Increased plasma levels of EpOMEs for MMTV-PyMT mice were significantly decreased by the treatment of Clo and SKF (n = 9). Data are presented as Mean ± SD. Statistical difference (***P < 0.001, **P < 0.01, *P < 0.05) was determined by one-way ANOVA followed by Tukey’s or Games-Howell post-hoc comparison.

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