Fig. 8: Antitumor effects of the CARM1 inhibitor SGC2085 in HCC. | Cell Death & Disease

Fig. 8: Antitumor effects of the CARM1 inhibitor SGC2085 in HCC.

From: PSMD14-mediated deubiquitination of CARM1 facilitates the proliferation and metastasis of hepatocellular carcinoma by inducing the transcriptional activation of FERMT1

Fig. 8

A The cytotoxicity of various concentrations of SCG2085 to MHCC-97h and PLC/PRF/5 cells was examined by a CCK-8 assay. B MHCC-97h cells were pretreated with the indicated concentrations of SGC2085 for 48 h. Transwell assays were conducted to evaluate the migratory and invasive potential of the cells. The accompanying figures depict representative images (left) and the corresponding statistical findings derived from the transwell assay (right). Nude mice with subcutaneous tumors formed by MHCC-97h cells were treated with vehicle control or SGC2085 (10 mg/kg; intraperitoneally (i.p.), three times each week) for 24 days (C). The tumor volume was measured every 3 days, and the data were presented as a line graph (D). The tumor weights of the xenografts from the different groups were calculated (E). (n = 3; *p < 0.05, **p < 0.01, and ***p < 0.001).

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