Fig. 7: Mechanistic scheme showing the FTO-mediated m6A methylation of Fas in regulating CD8+ T cell survival and effector response.
From: FTO controls CD8+ T cell survival and effector response by modulating m6A methylation of Fas
In WT CD8+ T cells, the presence of FTO effectively demethylates m6A modification on Fas mRNA, which leads to appropriate Fas expression and cell survival upon antigen stimulation. Compared to WT cells, FTO-deficient CD8+ T cells exhibit elevated m6A modification on Fas mRNA, which promotes its mRNA stability dependent on m6A reader protein IGF2BP3, resulting in subsequent increases of Fas expression and cell apoptosis upon cell activation.
