Fig. 7: Overexpression of INO80 or DHX15 restores glycolytic reprogramming in ARNTL-KO EC cells. | Cell Death & Disease

Fig. 7: Overexpression of INO80 or DHX15 restores glycolytic reprogramming in ARNTL-KO EC cells.

From: ARNTL-mediated INO80-DHX15 axis reprograms the glycolytic metabolism and augments the progression of endometrial carcinoma

Fig. 7

A Glycolytic activity in EFE-184 and AN3CA cells with ARNTL KO or INO80 overexpression evaluated by ECAR; B mitochondrial respiration in EC cells evaluated by OCR; C glucose uptake and lactate production in EC cells determined by colorimetry. ARNTL-KO EC cells were further administered Vector-DHX15 or Vector NC. D protein expression of DHX15 in cells determined by WB analysis; E glycolytic activity in cells evaluated by ECAR; F mitochondrial respiration in cells evaluated by OCR; G glucose uptake and lactate production in cells determined by colorimetry. All cellular experiments were performed in five biological replicates. Differences were analyzed by two-way ANOVA followed by Sidak’s multiple comparisons test (D, G) or Tukey’s multiple comparisons test (C). ****p < 0.0001.

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