Fig. 2: Expression of endogenous TACC1 protein in HNSCC. | Cell Death Discovery

Fig. 2: Expression of endogenous TACC1 protein in HNSCC.

From: Loss of TACC1 variant25 inducing cell proliferation and suppressing autophagy in head and neck squamous carcinoma

Fig. 2

A Schematic representation of TACC1 domains. This schematic diagram shows published TACC ___domain. B Western blot analysis. Because the anti-TACC1 ___domain antibody identifies all TACC1 variants proteins, stronger bands at ~70 and ~80 kDa in NHOK were TACC1v25 and/or 27 combined with RT-PCR. C Scansite analysis. Phosphorylation sites were predicted in TACC1v25 and full-length TACC1. The black words represent the possible phosphorylation site, while the green words represent the kinase or possible binding structure ___domain. D Immunofluorescence analysis. TACC1 variants include SPAZ ___domain encoding proteins that are primarily expressed in nucleus and perinucleus; however, TACC1 variants encoding protein containing TACC domains express in the nucleus, perinuclear region and cytoplasm. There was no significant difference of expression among the lines.

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