Fig. 1: Identification of radioresistant-related genes in NPC cells.

A Experimental procedure for CRISPR/Cas9 high-throughput screening in CNE2IR cells. B PCA analysis on IR/non-IR treated CNE2IR cells. C Ten genes were negatively selected according to significant copying number change (FDR < 0.01). D LUC7L2 was identified as a candidate radioresistant-related gene via CRISPR/Cas9 high-throughput screening and quantitative proteomic approach.