Fig. 3: The PI3K/AKT signaling network.
From: RING-finger E3 ligases regulatory network in PI3K/AKT-mediated glucose metabolism
The upstream and major downstream effectors of AKT signaling in glycogen synthesis, gluconeogenesis, glucose transport, and protein synthesis. IRS insulin receptor substrate, PI3K phosphatidylinositol 3-kinase, PTP1B protein-tyrosine phosphatase 1B, PIP3 phosphatidylinositol 3,4,5-trisphosphate, PDK1 phosphoinositide-dependent protein kinase 1, mTORC mechanistic target of rapamycin complex, FOXO forkhead box O, GSK3 glycogen synthase kinase 3, TSC2 tuberous sclerosis complex 2, RHEB Ras homolog enriched in brain.
