Fig. 6: TLR2 deficiency ameliorated SI-ALI and coagulation activation in the CLP mouse model. | Cell Death Discovery

Fig. 6: TLR2 deficiency ameliorated SI-ALI and coagulation activation in the CLP mouse model.

From: Neutrophil extracellular traps contribute to immunothrombosis formation via the STING pathway in sepsis-associated lung injury

Fig. 6

A H&E staining, Sirius Red staining, α-SMA, and fibrinogen immunohistochemical analysis of the lung tissues (n = 5; Scale bar: 50 μm). The proportions of the α-SMA-positive areas and fibrinogen-positive areas were calculated by Fiji/ImageJ software (n = 5). B Lung injury was semi quantified according to H&E staining. The lung injury score was recorded (n = 5). C The lung wet/dry ratio (n = 4). D The mRNA levels of TNF-α, IL-1β, and IL-6 in murine lung tissues (n = 5). E Western blot images of STING pathway and TF expression in lung tissues. Statistical analysis for three or more groups was carried out using 1-way ANOVA (A–D). *p < 0.05, **p < 0.01, ***p < 0.001.

Back to article page