Fig. 2: Post-transcriptional modifications and cofactors of SOX TFs. | Cell Death Discovery

Fig. 2: Post-transcriptional modifications and cofactors of SOX TFs.

From: SOX on tumors, a comfort or a constraint?

Fig. 2

Post-transcriptional modification of SOX TFs mainly includes acetylation [48], phosphorylation [41, 42, 120], methylation [40, 59], ubiquitination [45, 46] and SUMOylation [43, 44], which infects the translocation, activity and stability of SOX TFs. Cofactors interact with SOX TFs and exert co-activation [50,51,52,53] or co-repression [54,55,56,57] effects on the physiological and pathological functions of SOX TFs.

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