Fig. 4: SOX TFs acts as the hub of signaling pathways in the tumorigenesis.

SOX TFs in critical positions of the signaling pathway that mediates EMT [76, 82, 85, 87, 132, 78,79,80, 86], invasion and metastasis [91,92,93, 96, 135], proliferation and apoptosis [59, 97, 99, 123, 124, 128], stemness of cancer [104, 105, 107, 108, 110, 111].