Fig. 4: MACC1 is negatively correlated with KLF4 expression level. | Cell Death Discovery

Fig. 4: MACC1 is negatively correlated with KLF4 expression level.

From: MACC1 ablation suppresses the dedifferentiation process of non-CSCs in lung cancer through stabilizing KLF4

Fig. 4

A Volcano plot display the RNA-seq genome expression differences profile between H1299 shNC and shMACC1 (B) Overlap of RNA-seq data (absolute value > 1.5-fold, p < 0.05) with stem gene set. C, D Validation of KLF4 gene expression by RT-PCR (N = 3). **P < 0.01, two-tailed Student’s t-tests. Error bars: mean ± SD. E MACC1 and KLF4 levels from ten paired NSCLC tumors (T) and normal (N) tissues were evaluated by western blots. F The correlation between the levels of MACC1 and KLF4 was plotted. G–J Kaplan–Meier regression curve analysis of the overall survival (GSE3141 from GEO database) and first progression (from https://kmplot.com/) of lung cancer patients with high or low expression of KLF4 and MACC1. p < 0.05 indicates a significant difference regarding survival time or first progression time between the two groups.

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