Fig. 1: Follicle growth in Exoc1-G-cKO mice. | Cell Death Discovery

Fig. 1: Follicle growth in Exoc1-G-cKO mice.

From: Exocyst complex component 1 (Exoc1) loss in dormant oocyte disrupts c-KIT and growth differentiation factor (GDF9) subcellular localization and causes female infertility in mice

Fig. 1

Follicle growth in the ovaries of 4, 8, 10, and 12-week-old Exoc1-G-cKO (Exoc1flox/flox::Gdf9+/Cre) and control Exoc1-G-ctrl (Exoc1+/flox::Gdf9+/Cre) mice. A Representative Haematoxylin and Eosin staining images of Exoc1-G-cKO mice ovaries. No antral follicles were observed in Exoc1-G-cKO mice ovaries that were eight weeks old. No follicles were observed at any stage in 28-week-old Exoc1-G-cKO mice. Scale bar = 500 μm. B Representative Haematoxylin and Eosin staining images of primordial, primary, secondary and antral follicle in 4-week-old Exoc1-G-cKO ovary. Scale bar = 20 μm. C Follicle count in ovaries in Exoc1-G-cKO mice. No secondary follicles were observed in the Exoc1-G-cKO mice that were 10 and 12 weeks old. n = 3, Student’s t test.

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