Fig. 3: SnRNA-seq analysis revealed alterations of neuron in cortex after high-altitude TBI. | Cell Death Discovery

Fig. 3: SnRNA-seq analysis revealed alterations of neuron in cortex after high-altitude TBI.

From: High-altitude hypoxia aggravated neurological deficits in mice induced by traumatic brain injury via BACH1 mediating astrocytic ferroptosis

Fig. 3

A, B UMAP plot of 17,002 high-quality cells to show 10 main cell-types based on the expression of known marker genes, colored by cell type and cell origin respectively. C Expression of representative marker genes for each cell type. Gene expression violin plots are shown in log-scale Unique Molecular Identifiers (UMI). D The ratio of each cell type in LA-TBI and HA-TBI groups. E UMAP plot of neurons to show excitatory-neurons and inhibitory-neurons. F The ratio of two types neurons in LA-TBI and HA-TBI groups. G Expression of representative marker genes for excitatory-neurons and inhibitory-neurons. H The heatmap of DEGs in excitatory-neurons between two groups. I The KEGG pathways of up-regulated DEGs in excitatory-neurons. J, K The top 10 GO enrichments in BP, CC, MF in up-regulated (J) and down-regulated (K) DEGs. Each node signaled a GO term, and its size represented the gene number.

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