Fig. 5: HSP90-WWP1/WWP2-NEDD4L axis regulated radiation-induced ferroptosis of HeLa cells. | Cell Death Discovery

Fig. 5: HSP90-WWP1/WWP2-NEDD4L axis regulated radiation-induced ferroptosis of HeLa cells.

From: HSP90 regulates dCK stability and inhibits ionizing radiation-induced ferroptosis in cervical cancer cells

Fig. 5

A, B Evaluation of cell death in sh-Control and sh-HSP90 HeLa cells expressing WWP1/2 48 h after 8 Gy of IR irradiation. C, D Evaluation of lipid peroxidation in sh-Control and sh-HSP90 HeLa cells expressing WWP1/2 48 h after 8 Gy of IR exposure. E, F Analysis of cell death rate in co-expressing WWP1/2 and NEDD4L in HeLa cells 48 h following 8 Gy of IR irradiation. The error bars show the means ± SD from three separate repeats. p < 0.05 for *, p < 0.01 for **, and p < 0.001 for ***. Using a two-tailed unpaired student’s t-test, P values were determined.

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