Fig. 3: Diverse biological functions of the CRIP family. | Cell Death Discovery

Fig. 3: Diverse biological functions of the CRIP family.

From: Cysteine-rich intestinal protein family: structural overview, functional diversity, and roles in human disease

Fig. 3

A The CRIP family and epithelial-mesenchymal transition (EMT). CRIP1 induces EMT by activating the Wnt/β-catenin signaling pathway and the GSK 3/mTOR signaling pathway. Additionally, CRIP1 interacts with BBOX1 and STUB1 to promote the ubiquitination and degradation of BBOX1, leading to nuclear accumulation of β-catenin that facilitates EMT induction. B The CRIP family and cell death. CRIP1 enhances Fas ubiquitination and degradation, inhibits caspase activation, and suppresses cellular apoptosis. CRIP1 inhibits apoptosis through modulation of the PI3K-Akt pathway. CRIP2 promotes TRAP1 expression to regulate cell apoptosis via mitochondrial pathways. Moreover, CRIP1 increases proteasome activity and autophagy through the CRIP1/USP7/PA200 axis. CRIP2 interacts with ATOX1 and ATOX1 transfers copper to CRIP2 causing ubiquitination and degradation of CRIP2 to increase ROS levels and activate autophagy. C The CRIP family and immunity. CRIP1 binds to NF-κB promoting its nuclear translocation while transcriptionally activating CXCL1/5 and promotes chemotactic migration and recruitment of MDSCs. Additionally, CRIP1 interacts with CREB1 to promote the expression of CCL5, recruit macrophages to promote the secretion of TNF-α, and finally enhance lymphatic permeability to cause tumor cell migration.

Back to article page