Fig. 5: Ccl2 deficiency substantially attenuates anxiety and reverses anxiety-related neuronal changes in highly myopic mice.
From: CCL2-mediated inflammatory pathogenesis underlies high myopia-related anxiety
a Representative maps of animal tracking (black lines) in the dark showed significantly reduced anxiety levels in Ccl2-deficient highly myopic mice than in wild-type highly myopic mice in OFT. b Representative maps of animal tracking (black lines) in the dark showed significantly reduced anxiety levels in Ccl2-deficient highly myopic mice than in wild-type highly myopic mice in the EPM test. c Representative Golgi images of the dendritic spines in BLA and ventral hippocampus of mice. Scale bars: 5 μm. d High myopia modeling increased the spine density of BLA pyramidal neurons and decreased the spine density of ventral hippocampus neurons, which were partially reversed by Ccl2 deficiency. Data are mean ± SD. n = 12 in each group (a, b); n = 4 in each group (c, d) . The level of significance was detected with Student’s t-test (a, b) or one-way ANOVA (d). ****P < 0.0001, ***P < 0.001, **P < 0.01, *P < 0.05, ns P > 0.05.
