Fig. 7: Schematic model for the process of macrophage-mediated trogocytosis in destroying human schistosomes. | Cell Discovery

Fig. 7: Schematic model for the process of macrophage-mediated trogocytosis in destroying human schistosomes.

From: Macrophage-mediated trogocytosis contributes to destroying human schistosomes in a non-susceptible rodent host, Microtus fortis

Fig. 7

Stimulation of Schistosoma antigens leads to an increase in intracellular Ca2+ concentration in M. fortis macrophages, further inducing the activation of NFAT. The activation of NFAT can induce the transcriptional expression of multiple genes, causing macrophage adhesion to the surface of schistosomula through C3–CR3 interaction. Subsequently, the macrophages destroy the parasites through trogocytosis, ultimately leading to impaired growth, atrophy, and even death of schistosomula.

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