Fig. 3: Molecular basis of MCH recognition by MCHR2.
From: Mechanisms of ligand recognition and activation of melanin-concentrating hormone receptors
a Cross-section of the MCH-binding pocket in MCHR2. b‒f Detailed molecular interactions between MCH (depicted in medium violet red) and MCHR2 (shown in teal). Hydrogen bonds are highlighted with gray dashed lines. g Functional data derived from alanine mutations of residues within the MCHR2 binding pocket, represented as ΔpEC50 values. ΔpEC50 represents the difference in pEC50 values between the WT and the mutants of MCHR2. Data are presented as mean ± SEM. from three independent experiments performed in triplicate and analyzed by two-sided one-way ANOVA with Tukey’s test compared with WT. NA no activity; *P < 0.05; **P < 0.01; ***P < 0.001; ****P < 0.0001.
