Fig. 3: Transplantation of M cells increased E2 and P4 levels of the naturally aging monkeys.
From: Stem cell transplantation extends the reproductive life span of naturally aging cynomolgus monkeys
a Experimental design to test the effects of M-cell transplantation on hormone level and fertility potential of naturally aging monkeys. b Bar graphs illustrated the levels of E2 at the early follicular phase of the menstrual cycle in control and treated monkeys before treatment and after 3-, 6-, 8-month treatment. Before treatment, n = 3 monkeys (control), n = 7 monkeys (treated). After 3- and 6-month treatment, n = 3 monkeys (control), n = 6 monkeys (treated, except the pregnant monkey T02). After 8-month treatment, n = 3 monkeys (control), n = 5 monkeys (treated, except the monkey T02 due to lactation period and T07 due to poor healthy condition during this period), ns no significance, *P < 0.05 (two-tailed t-test). c Line graphs illustrated the P4 level of monkeys before (left panel) treatment and 3 months (right panel) after treatment. Before treatment, n = 3 monkeys (control), n = 7 monkeys (treated). After 3-month treatment, n = 3 monkeys (control), n = 6 monkeys (treated, except the pregnant monkey T02). *P < 0.05 (multiple t-tests). d Line plots illustrated the P4 levels of representative control (C03) (upper panel) and treated (T01) (lower panel) monkeys before treatment and after 3-, 6- and 8-month treatment.
