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Data availability
All data including source data and statistics in this study are included in main text or Supplementary information, Data S1. NGS data has been deposited to GEO (GSE225183). Other materials and custom codes are available via reasonable requests from the corresponding authors.
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Acknowledgements
This work is supported by discretionary funds and DoD PRMRP IIAR (W81XWH-21-1-0019) to S.C. We thank support from various Yale core facilities; Systems Biology Institute; Department of Genetics; Dean’s Office of Yale School of Medicine and the Office of Vice Provost for Research. We thank J. Nikolaus, G. Terwilliger, A.J. Nugent, M. Schadt, B. Goldman-Israelow and F. Yang, L. Peng, X. Zhou, F. Zhang and others for technical assistance.
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Contributions
S.C. and Z.F. conceptualized and designed the study. Z.F., V.S.M. and C.L. performed most of experiments and analyzed the data. P.A.R., X.S., and K.S. assisted data analysis. X.L. and M.B. assisted experiments. Y.X. and A.L. provided scientific support. C.J.B. performed mouse necropsy and histopathologic analysis. S.C. and C.L. supervised the study. Z.F., P.A.R., C.J.B., C.L. and S.C. wrote the manuscript with feedback from all authors.
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Competing interests
A patent has been filed related to this study by Yale University. S.C. is a founder of EvolveImmune, Cellinfinity, Chen Consulting, and Chen Tech, all unrelated to this study.
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Fang, Z., Monteiro, V.S., Renauer, P.A. et al. Polyvalent mRNA vaccination elicited potent immune response to monkeypox virus surface antigens. Cell Res 33, 407–410 (2023). https://doi.org/10.1038/s41422-023-00792-5
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DOI: https://doi.org/10.1038/s41422-023-00792-5
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