Fig. 12: Delivery of miRs and GDNF for axonal regeneration.
From: Biomaterial-based regenerative therapeutic strategies for spinal cord injury
a Schematic diagram of the fabrication of the 3D fiber-hydrogel scaffold. b Cumulative release of negative miR (Neg miR) and GDNF. c Representative fluorescence images of neurofilament 200 (NF200) staining. d Quantification analysis of NF200+ area. e Representative fluorescence images of 5-hydroxytryptamine (5-HT) staining. f Quantification analysis of 5-HT+ area. g Representative fluorescence images of calcitonin gene-related peptide (CGRP) staining. h Quantification analysis of CGRP+ area. i BBB scores in the presence of MP. j Von Frey Hair test in the presence of MP. NF200 is a marker of mature axons; 5-HT and CGRP are markers for different types of axons, labeling serotonergic and sensory axons, respectively. Reproduced under terms of the CC-BY license177. Copyright 2021, Wiley‐VCH GmbH.
