Table 2 Clinical trials of functional bioscaffolds to treat SCI.
From: Biomaterial-based regenerative therapeutic strategies for spinal cord injury
Scaffold type | NCT number | Treatment | SCI phase/Location | AIS grade | Clinical phase | Country |
|---|---|---|---|---|---|---|
Neuro-spinal scaffold | NCT02138110 | Scaffold implantation | Acute T2-T12 | A | N/A | The United States |
Neuro-spinal scaffold | NCT03762655 | Standards of care open spine surgery with or without scaffold implantation | Acute T2-T12 | A | N/A | The United States |
Functional collagen scaffold | NCT02510365 | Scaffold transplant | Acute C4-T12 | A | I | China |
Functional collagen scaffold | NCT03966794 | Epidural electrical stimulation versus Scaffold transplant with epidural electrical stimulation | Acute or chronic C4-T12/L1 | A | I/II | China |
NeuroRegen scaffold | NCT02352077 | Scaffold transplant with MSCs or BMMCs | Chronic C5-T12 | A | I | China |
NeuroRegen scaffold | NCT02688062 | Scaffold transplant with BMMCs versus Surgical intradural decompression and adhesiolysis | Chronic Thoracic level | A | I/II | China |
NeuroRegen scaffold | NCT02688049 | Scaffold transplant with 10 million cells of MSCs or NSCs | Chronic C5-T12 | A | I/II | China |
