Abstract
Background
Prediabetes is a crucial period for preventing and managing diabetes. This study aimed to explore the effects of CYP2R1/GC gene polymorphisms on vitamin D3 supplementation responsiveness in prediabetes.
Methods
A total of 240 prediabetic participants received orally 1600 IU of vitamin D3 or placebo daily for 24 weeks.
Results
CYP2R1 rs12794714 AA carriers had less increased 25(OH)D3 levels compared with GG carriers after supplementation (3.42 (0.05, 6.79) vs. 8.49 (6.14, 10.83), P = 0.038). Moreover, GC rs4588 GA carriers had less increased 25(OH)D3 levels compared with GG carriers (4.71 (2.64, 6.79) vs. 8.17 (6.37, 9.98), P = 0.033); it also had lower supplementation responsiveness (0.35 (0.14, 0.91), P = 0.032). GC rs4752 AG carriers had higher supplementation responsiveness compared with AA carriers (3.48 (1.05, 11.59), P = 0.042).
Conclusions
The results indicated that CYP2R1 rs12794714, GC rs4588, and GC rs4752 polymorphism were associated with vitamin D3 supplementation responsiveness in prediabetes.
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Data availability
The data generated or analyzed during this study are available in this published article and its supplementary information files. Data will be made available from the corresponding author on reasonable request.
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Acknowledgements
Thanks to Sinopharm Xingsha Pharmaceuticals (Xiamen) Co., Ltd. and Zhendong Health Industry Group Co., Ltd. for providing intervention and placebo products. Furthermore, we thank the participants for their willingness in this study.
Funding
This research was supported by National Natural Science Foundation of China (Grant no. 82173515, 81872626, 82003454).
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Authors and Affiliations
Contributions
Study concept and design: WL, XL, PN, ZX and YZ. Data collection: PN, ZX, YZ, DZ and YL. Data analysis and manuscript-draft: PN, ZX and YZ. Manuscript-review: DZ and YL. Study supervision of the project: WL and XL.
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The authors declare no competing interests.
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Data collection conducted according to the guidelines of the Declaration of Helsinki. The study was approved by Medical Ethics Committee of Zhengzhou University (ZZUGZR2018-035) and registered at the Chinese Clinical Trial Registry (ChiCTR1900024872). All individuals provided written informed consent.
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Ni, P., Xu, Z., Zhang, Y. et al. Effect of CYP2R1 and GC gene polymorphisms on serum 25(OH)D response to vitamin D3 supplementation in prediabetes. Eur J Clin Nutr (2025). https://doi.org/10.1038/s41430-024-01564-z
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DOI: https://doi.org/10.1038/s41430-024-01564-z
