Fig. 3

Average increase in effect-size for the different comparisons. Average increase in effect sizes for: Extreme AD cases (NEA = 1,073), of which early onset cases (NeEA = 464), late onset cases (NlEA = 609); centenarian controls (NEC = 255); normal controls (NNC = 1,664). 95% confidence intervals were estimated by random sampling (S = 10,000)