Table 1 Evaluation of CHD_PRSCS, multiPGSCHD, and extendedPGSCHD in the Mayo Clinic Biobank.

From: A linear weighted combination of polygenic scores for a broad range of traits improves prediction of coronary heart disease

Model

PGS OR (95% CI)

R2 (95% CI)

AUC (95% CI)

Precision, recall

Base

 

0.170 (0.162–0.180)

0.767 (0.761–0.774)

0.211, 0.718

CHD_PRSCS

1.50 (1.45–1.56)

0.195 (0.186–0.206)

0.782 (0.776–0.789)

0.210, 0.747

MultiPGSCHD

1.66 (1.60–1.71)

0.208 (0.198–0.218)

0.790 (0.783–0.796)

0.231, 0.715

ExtendedPGSCHD

1.70 (1.64–1.76)

0.211 (0.202–0.222)

0.792 (0.785–0.798)

0.214, 0.764

  1. The base model included age, sex, and 10 PCs and the other models additionally included a PGS.
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