Fig. 2: In vitro analysis of c.1543C > T variant in TOGARAM2.
From: Genetic heterogeneity in hereditary hearing loss: Potential role of kinociliary protein TOGARAM2
A Quantitative mRNA expression levels of TOGARAM2 in wild type isogenic monoclonal clones compared to monoclonal TOGARAM2 (c.1543 C > T) knock-ins. Statistical analysis was performed using ANOVA, and data are presented as mean ± SD normalized to HPRT1 expression. Significant differences are indicated with an asterisk (**p ≤ 0.01, ***p ≤ 0.001) when compared to HEK293. B Overall quantitative mRNA expression levels of TOGARAM2 in wild type isogenic clones versus TOGARAM2 (c.1543 C > T) knock-ins. Statistical analysis was conducted using a student’s t-test, and data are shown as mean ± SD normalized to HPRT1 expression. Significant differences are denoted with an asterisk (*p ≤ 0.01) when compared to controls.
