Fig. 6: Immune GWAS loci are enriched for CD28-sensitive genes. | Genes & Immunity

Fig. 6: Immune GWAS loci are enriched for CD28-sensitive genes.

From: Genomic profiling of T-cell activation suggests increased sensitivity of memory T cells to CD28 costimulation

Fig. 6

A Enrichment of TCR- and CD28-sensitive genes in immune-mediated disease loci (ALL allergies, AST asthma, CD Crohn’s disease, UC ulcerative colitis, CeD coeliac disease, T1D type-1 diabetes, RA rheumatoid arthritis, SLE systemic lupus erythematosus, MS multiple sclerosis, PSO psoriasis). Alzheimer’s disease (AD), bone mineral density (BMD), LDL cholesterol (LDL) and schizophrenia (SCZ) are used as negative controls. B MS-associated locus containing two genes, ZC2HC1A and IL7, that are CD28-sensitive. In the upper panel are indicated all the SNPs in LD (red) with reported GWAS index variant, rs1021156. Of these, two variants highlighted in grey, rs3808619 and rs60486739, overlap CD28-upregulated H3K27ac peaks and are predicted to disrupt an IRF-binding site.

Back to article page