Table 1 Number of patients, characteristics, and number of direct and inverse comorbidities for each of the 11 most prevalent chromosome abnormalities in the Danish population.
From: Comorbidity landscape of the Danish patient population affected by chromosome abnormalities
Chromosome abnormality | ICD-10 diagnosis code(s) | Number of patients | Number of direct comorbidities | Number of inverse comorbidities | Median age at first diagnosis (SD) | Median age at death (SD) | Median follow-up years (SD) |
|---|---|---|---|---|---|---|---|
Patau syndrome (trisomy 13) | Q91.4, Q91.5, Q91.6, Q91.7 | 72 | 21 | 0 | 0.00 (12.47) | 0.02 (12.93) (n = 55) | 0.08 (7.38) |
Edwards syndrome (trisomy 18) | Q91.0, Q91.1, Q91.2, Q91.3 | 175 | 29 | 0 | 0.00 (14.72) | 0.02 (9.64) (n = 126) | 0.18 (7.58) |
Down syndrome (trisomy 21) | Q90 | 3,474 | 236 | 56 | 21.29 (23.00) | 56.65 (19.66) (n = 931) | 16.20 (6.64) |
Female Down syndrome | 1,601 | 181 | 34 | 22.36 (23.23) | 56.37 (19.23) (n = 438) | 15.87 (6.63) | |
Male Down syndrome | 1,873 | 194 | 32 | 20.30 (22.79) | 57.18 (20.06) (n = 493) | 16.41 (6.65) | |
Non-mosaic Down syndrome | Q90.0 | 1,050 | 211 | 10 | 0.24 (17.69) | 51.31 (25.56) (n = 166) | 16.90 (6.27) |
Mosaic Down syndrome | Q90.1 | 62 | 15 | 0 | 7.89 (19.73) | 56.65 (23.78) (n = 11) | 18.25 (6.13) |
Klinefelter syndrome (47,XXY) | Q98.0, Q98.1, Q98.2, Q98.4 | 764 | 88 | 1 | 28.12 (18.11) | 58.32 (15.89) (n = 53) | 18.97 (5.34) |
Triple X syndrome | Q97.0 | 65 | 6 | 0 | 3.13 (11.74) | NAa | 13.35 (6.62) |
XYY syndrome | Q98.5 | 81 | 12 | 0 | 12.50 (12.75) | NAa | 17.95 (5.04) |
Turner syndrome (45,X) | Q96 | 870 | 119 | 9 | 16.75 (19.19) | 61.41 (20.89) (n = 86) | 18.86 (5.67) |
Non-mosaic Turner syndrome | Q96.0 | 241 | 48 | 0 | 12.31 (15.08) | 55.14 (22.64) (n = 14) | 19.70 (5.30) |
Mosaic Turner syndrome | Q96.3 | 58 | 1 | 0 | 10.36 (14.70) | NAa | 12.49 (6.28) |
Wolf–Hirschhorn syndrome | Q93.3 | 51 | 37 | 0 | 2.02 (12.06) | 0.62 (15.31) (n = 8) | 10.79 (7.15) |
Cri-du-chat syndrome | Q93.4 | 62 | 32 | 0 | 6.28 (18.24) | 24.29 (22.58) (n = 9) | 15.69 (7.08) |
Angelman syndrome | Q93.5C | 80 | 33 | 0 | 5.09 (14.95) | NAa | 13.88 (5.93) |
Fragile X syndrome | Q99.2 | 206 | 29 | 0 | 7.64 (19.27) | 68.88 (22.44) (n = 7) | 16.77 (6.13) |
Female Fragile X syndrome | 58 | 3 | 0 | 10.47 (19.35) | NAa | 14.54 (6.17) | |
Male Fragile X syndrome | 148 | 22 | 0 | 6.61 (19.29) | 65.04 (25.22) (n = 5) | 17.27 (6.10) |
