Fig. 5: The heteroplasmy level of paternally transmitted variants is inversely correlated with mitochondrial DNA (mtDNA) content of the specimen. | Genetics in Medicine

Fig. 5: The heteroplasmy level of paternally transmitted variants is inversely correlated with mitochondrial DNA (mtDNA) content of the specimen.

From: Interference of nuclear mitochondrial DNA segments in mitochondrial DNA testing resembles biparental transmission of mitochondrial DNA in humans

Fig. 5

For the individuals with multiHets, when multiple sample types were evaluated, the heteroplasmic level of the variants of paternal origin were correlated with the mtDNA of the sample. The heteroplasmy level of the variants of paternal origin is inversely correlated with the mtDNA content. a The correlation of heteroplasmy level of the variants of paternal origin with the mtDNA content of the specimen in family A. b The correlation of heteroplasmy level of the variants of paternal origin with the mtDNA content of the specimen in family B. c The correlation of heteroplasmy level of the variants of paternal origin with the mtDNA content of the specimen in family C. d The correlation of heteroplasmy level of the variants of paternal origin with the mtDNA content of the specimen in family D. R correlation coefficient. Student’s t-test P < 0.05 is considered a significant correlation.

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