Fig. 9

aPC mitigates human CD4⁺ T-cell mediated GvHD. a, b Recipient NSG-Ab DR4 mice were irradiated with 2 Gy and transplanted 4 h later with 4 × 10⁶ of human CD4⁺ T-cells (HLA-DR4⁻) without (hCD4⁺) or with (hCD4⁺(aPC)) aPC-preincubation. Survival (a Kaplan–Meier curve) and physical parameters (b clinical score) are shown; pooled data from three independent experiments each with two recipients. c, d Photomicrographs depicting typical morphology in liver, small intestine (SI), colon, and skin; haematoxylin and eosin stained section (c), size bar 50 µm and bar graph summarizing histological disease scores; mean value ± SEM (five mice per group, d). *P < 0.05, **P < 0.01; ***P < 0.001 (a log-rank test; b ANOVA; d t-test)