Fig. 3
Discovery and replication of rs14666075 association signal. a Forest plot of the discovery of rs146662075 variant. Cohort-specific odds ratios are denoted by boxes proportional to the size of the cohort and 95% CI error bars. The combined OR estimated for all the data sets is represented by a diamond, where the diamond width corresponds to 95% CI bounds. The p-value for the meta-analysis (Meta P) and for the heterogeneity (Het P) of odds ratio is shown. b Kaplan–Meier plot showing the cumulative incidence of T2D for a 11 years follow-up. The red line represents the T carriers and in light blue, C carriers are represented (n = 1,652, cases = 158). c Forest plot after excluding controls younger than 55 years, OGTT >7.8 mmol l−1, and controls with family history of T2D in both the discovery and replication cohorts when available
