Fig. 8 | Nature Communications

Fig. 8

From: Acetylation accumulates PFKFB3 in cytoplasm to promote glycolysis and protects cells from cisplatin-induced apoptosis

Fig. 8

Inhibition of PFKFB3 cooperates with cisplatin to inhibit xenograft growth. a Combined use of cisplatin and PFK15 is more efficient in inhibiting xenograft tumor growth than single treatment. Xenograft experiment followed by cisplatin or PFK15 injection was described in the Methods section. Xenograft tumors were collected and photographed. b, c Quantification of b average volume and c weight of xenograft tumors from a is shown. Twelve tumors from individual mice were included in each group. Data are presented as mean ± s.d., and statistical analyses were performed by using one-way ANOVA with Bonferroni’s post-test. *P< 0.05 and ***p < 0.001 for the indicated comparison; n.s., not significant. d A working model that PFKFB3 K472 acetylation plays a key role in protecting cells from cisplatin-induced apoptosis

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