Fig. 6 | Nature Communications

Fig. 6

From: Loss of 5-methylcytosine alters the biogenesis of vault-derived small RNAs to coordinate epidermal differentiation

Fig. 6

Summary of VTRNA1.1 processing into svRNA4. a Expression of both NSUN2 and SRSF2 (e.g. in progenitor cells) result in high levels of VTRNA1.1 methylation (CH3) and high levels of svRNA4 and repressed differentiation. b No NSUN2 in the presence of SRSF2 suppresses formation of svRNA4 and allows differentiation. c Lack of expression of both NSUN2 and SRSF2 release VTRNA1.1 from SRSF2 binding and increases the levels of svRNA4

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