Fig. 8
From: Circular RNA CircFndc3b modulates cardiac repair after myocardial infarction via FUS/VEGF-A axis
Proposed mechanism of circFndc3b mediated cardiac repair: AAV9 circFndc3b therapy increases circFndc3b levels in the post-MI heart leading to its interaction with FUS, which impacts VEGF-A signaling. This enhances angiogenesis, limits infarct size, and preserves post-MI cardiac function and integrity mediated cardiac repair. FUS, Fused in sarcoma; VEGF-A, Vascular endothelial growth factor
