Fig. 1: Integrated genomic and transcriptomic analysis of UTUC cancers. | Nature Communications

Fig. 1: Integrated genomic and transcriptomic analysis of UTUC cancers.

From: Modeling biological and genetic diversity in upper tract urothelial carcinoma with patient derived xenografts

Fig. 1

a Somatic genomic landscape of 80 UTUC tumors analyzed by MSK-IMPACT sequencing stratified by RNA sequencing analysis into luminal-like and basal-like subtypes defined using the BASE47 classifier (K = 2)15, and 5 subtypes based on a consensus molecular classification of muscle-invasive bladder cancer16. Tumor mutation burden per megabase (Mb) is indicated in log2 scale for each sample. b Clustering analysis of RNA-seq data from 80 UTUC tumor samples based on the BASE47 classifier (basal marks shown as a turquoise vertical bar; luminal marks shown as a salmon vertical bar). Analysis of genes expressed in cancer cells of a basal-like phenotype (KRT14, CDH3, CD44, KRT5, EGFR, KRT6A/B) is also shown (color key on the top of b). c The number of tumors with oncogenic/likely oncogenic and variants of unknown significance in 17 genes frequently mutated in UTUC. Source data for a and b are provided as a Source Data file.

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