Fig. 3: Co-expression network analyses.
From: Multiscale causal networks identify VGF as a key regulator of Alzheimer’s disease
a, c Top GO annotations for gene (a) and protein (c) co-expression modules. The x- and y-axis represent the best GO term associated with each module and the −log 10(FDR) of the enrichment, respectively. The color of the bars represents the module names. In bold are the four modules enriched for genes in the union of the DE signatures. b, d Module enrichments for DE genes (b) and proteins (d). The circos plot depicts the enrichment of each module for DE genes or proteins; the “hotness” of the color represents the magnitude of the −log 10(adjusted p value) of the enrichment for the corresponding signature list. The traits are defined as 1 through 12; in bold are the modules enriched for the union of the DE signatures.
