Fig. 9: Expression of TMEM16A correlates with cyst size in ADPKD.
From: Cyst growth in ADPKD is prevented by pharmacological and genetic inhibition of TMEM16A in vivo
Reanalysis of the public data set (GSE7869) from a global gene profiling study on renal cysts reported by Song et al.31. The data set comprises microarray expression data from cysts of different sizes from n = 5 PKD1-patients and from n = 3 kidneys of healthy patients. Reanalysis was performed using the Transcriptome Analysis Console (Thermo Fisher). Inspecting the probe covering TMEM16A (ANO1), a significant increase in TMEM16A-mRNA expression was found in the cystic tissue when compared to normal samples. Increase in TMEM16A-expression correlated with cyst size. Mean and error bars indicating ±SEM. Source data are provided as a Source Data file.
